Hi Trevor,
What Browser are you using? In the IDE you can select what you have installed.
If you run the app on your DEV PC and use Casini/IISExpress does it work? IISExpress is little more forgiving around permissions and should simply work.
Is the AppPool also set for 64 bit? What happens if you set it for 32 bit?
Oh, and just thought of something, quite often all you have to do is copy the web.config file into the app folder, For some reason a Deployment package does not include it. Your logs show PATH NOT FOUND, seems like it is missing or the folder permissions are not set correctly, try setting them to full access with read/write.
And what happens if you create a simply one button CR WEB app and preview a report with saved data, no DB log on or parameters etc.
Does that work?
Don